June 15, 2023
A new study published in Open Forum Infectious Diseases co-authored by OHT’s Ramanan Laxminarayan and Eili Klein showed that discontinuing antibiotics early, three to four days after initiation, was not associated with higher mortality in a large cohort of US patients hospitalized with suspected culture-negative serious infection (CNSI). Early discontinuation of antibiotics was also not linked to greater odds of hospital discharge to hospice care compared to patients who received a full five-day course of antibiotics. In combination with further studies on post-discharge health outcomes following early antibiotic discontinuation, these findings can help promote antibiotic stewardship and best practices among medical professionals.
Read the full manuscript here.