Antimicrobial resistance (AMR) is a global issue with increasingly severe consequences for the world economy and human health. Vaccines reduce AMR by preventing infectious diseases, but the benefits of vaccination campaigns in improving health and economic outcomes have yet to be extensively quantified. ARVac, a consortium of One Health Trust (founded as CDDEP), Yale, Berkeley, Imperial College London, and Princeton, brings together experts in infectious disease modeling to assess the health and economic benefits of potential, new, and current vaccines targeting pathogens of public health relevance.
Vaccines and AMR
Many vaccines, both those in current use and those in the pipeline, have the potential to reduce the AMR disease burden, and thereby save lives, via two mechanisms:
- A lower overall burden of infections reduces the transmission of resistant and susceptible pathogens.
- Fewer infections reduce the need for antimicrobials, thereby alleviating the selection pressure for resistant pathogenic strains. Ultimately, the drop in resistant cases leads to fewer untreatable infections and more lives saved.
Synergizing Immunization and AMR Mitigation Strategies
Despite evidence linking vaccination to AMR mitigation, funding for research at the clinical and policy levels is inadequate. One Health Trust, in collaboration with the World Health Organization, is initiating a global effort to increase awareness of the value of vaccines in mitigating AMR. The project spans the 15 countries in Africa and Asia that are in the Global Antibiotic Resistance Partnership (GARP), with the possibility to expand to other low- and middle-income countries. The GARP network is a major platform for communicating the role of vaccines.
- Imperial College London
Funding from the Bill & Melinda Gates Foundation and the Wellcome Trust.
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